Optimal Control of Treatments in a Two-strain Tuberculosis Model

نویسندگان

  • E. Jung
  • S. Lenhart
  • Z. Feng
  • Glenn Webb
  • Z. FENG
چکیده

Optimal control theory is applied to a system of ordinary differential equations modeling a two-strain tuberculosis model. Seeking to reduce the latent and infectious groups with the resistant-strain tuberculosis, we use controls representing two types of treatments. The optimal controls are characterized in terms of the optimality system, which is solved numerically for several scenarios.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The effect of chemical and biological fertilizers on leaf characteristics, yield and nutrient uptake and consumption efficiency, phosphorus and sulfur in Camelina sativa L.

The aim of this study was to investigate the effect of chemical fertilizers of nitrogen, phosphorus, sulfur and biofertilizer on some growth indicators of Camelina sativa L. experimental plant during the crop year 2016 in a farm located in Kazerun and as a factorial in the form of complete randomized block design with three replications. Treatments include fertile biofertilizer 2 containing pho...

متن کامل

In-silico Designing of Immunogenic Construct Based on Peptide Epitopes Using Immuno-informatics Tools Against Tuberculosis

Background and Aim: Mycobacterium tuberculosis is a health problem in countries. Despite the global prevalence of tuberculosis and the lack of appropriate drugs, further progress is still needed with the help of modern methods of preparing epitope-based vaccines for tuberculosis. Materials and Methods: In this study, specific T and B cell epitopes required for producing chimeric vaccines with ...

متن کامل

Trajectory Tracking of Two-Wheeled Mobile Robots, Using LQR Optimal Control Method, Based On Computational Model of KHEPERA IV

This paper presents a model-based control design for trajectory tracking of two-wheeled mobile robots based on Linear Quadratic Regulator (LQR) optimal control. The model proposed in this article has been implemented on a computational model which is obtained from kinematic and dynamic relations of KHEPERA IV. The purpose of control is to track a predefined reference trajectory with the best po...

متن کامل

T-lymphocyteCell InjectionCancer Immunotherapy‎: an Optimal Control Approach

We consider amathematical model in the form of a system of ordinary differential equations (ODE) foroptimally administrating cancer treatments. The ODE systemdynamics characterized by locating equilibrium points and stability propertiesare determined by linearization and usingappropriate Lyapunovfunctions. By applying optimal control theory, we seek to minimize the cost function associated with...

متن کامل

A New model of Equivalent Modulus Derived from Repeated Load CBR Test

This paper presents a new model of equivalent modulus derived from the Repeated Load CBR (RL-CBR) test without strain gauge. This model is an updated version of Araya et al. model (2011), the update consists of using the vertical strain as weighting factor instead of vertical displacement in the mean vertical and horizontal stresses calculation. The accuracy of equivalent modulus was improved b...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2002